Prohibitin levels regulate OMA1 activity and turnover in neurons
نویسندگان
چکیده
منابع مشابه
Stress-induced OMA1 activation and autocatalytic turnover regulate OPA1-dependent mitochondrial dynamics.
The dynamic network of mitochondria fragments under stress allowing the segregation of damaged mitochondria and, in case of persistent damage, their selective removal by mitophagy. Mitochondrial fragmentation upon depolarisation of mitochondria is brought about by the degradation of central components of the mitochondrial fusion machinery. The OMA1 peptidase mediates the degradation of long iso...
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ژورنال
عنوان ژورنال: Cell Death & Differentiation
سال: 2019
ISSN: 1350-9047,1476-5403
DOI: 10.1038/s41418-019-0469-4